Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants

• Published in: 3 Biotech Vol. 12; no. 12; p. 343
• Main Authors: Mullaguri, Sai Charitha, Akula, Sravani, Sahoo, Partha Sarathi, Ashireddygari, Vigneshwar Reddy, Mupparapu, Vyshnavika, Silveri, Ravalika, Prasad Burra, V L S, Kancha, Rama Krishna
• Format: Report
• Language: English
• Published: 01.12.2022

KRAS is the most frequently mutated oncogene in solid cancers, and inhibitors that specifically target the KRAS-G12C mutant were recently approved for clinical use. The limited availability of experimental data pertaining to the sensitivity of KRAS-non-G12C mutants towards RAS inhibitors made it dif...