Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzogquinazoline Derivatives (In Vitro)

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 24
• Main Authors: Abuelizz, Hatem A, Marzouk, Mohamed, Bakheit, Ahmed H, Awad, Hanem M, Soltan, Maha M, Naglah, Ahmed M, Al-Salahi, Rashad
• Format: Journal Article
• Language: English
• Published: 15.12.2020

A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[g]quinazolines (1-17) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2-targeting, antiproliferative, and antiapoptotic activities against breast MCF-7 and liver HepG2 cells. Flow cytometry was used to det...