A highly reproducible method for the measurement of 6-O-methyl-11 Cdiprenorphine and its radio-metabolites based on solid-phase extraction and radio-high-pressure liquid chromatography

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 64; no. 1; p. 30
• Main Authors: Fairclough, Michael, McMahon, Adam, Barnett, Elizabeth, Matthews, Julian, Brown, Christopher A, Jones, Anthony
• Format: Journal Article
• Language: English
• Published: 01.01.2021

Described here is a method for the measurement of the radio-metabolites of the positron emission tomography radiotracer [6-O-methyl-11 C]diprenorphine ([11 C]diprenorphine) using in-line solid-phase extraction (SPE) combined with radio-high-pressure liquid chromatography analysis. We believe that th...