X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14a-Demethylase (CYP51)

• Published in: The Journal of biological chemistry Vol. 283; no. 22; pp. 15152 - 15159
• Main Authors: Eddine, Ali Nasser, von Kries, Jens P, Podust, Mikhail V, Warrier, Thulasi, Kaufmann, Stefan HE, Podust, Larissa M
• Format: Journal Article
• Language: English
• Published: 01.05.2008
• Subjects: Mycobacterium tuberculosis

A universal step in the biosynthesis of membrane sterols and steroid hormones is the oxidative removal of the 14a-methyl group from sterol precursors by sterol 14a-demethylase (CYP51). This enzyme is a primary target in treatment of fungal infections in organisms ranging from humans to plants, and d...