Quantification of Urinary Aflatoxin B sub(1) Dialdehyde Metabolites Formed by Aflatoxin Aldehyde Reductase Using Isotope Dilution Tandem Mass Spectrometry

• Published in: Chemical research in toxicology Vol. 21; no. 3; pp. 752 - 760
• Main Authors: Johnson, Denise, Egner, Patricia, OBrian, Greg, Glassbrook, Norman, Roebuck, Bill, Sutter, Thomas, Payne, Gary, Kensler, Thomas, Groopman, John
• Format: Journal Article
• Language: English
• Published: 01.01.2008
• Subjects: Aspergillus flavus

The aflatoxin B sub(1) aldehyde reductases (AFARs), inducible members of the aldo-keto reductase superfamily, convert aflatoxin B sub(1) dialdehyde derived from the exo- and endo-8,9-epoxides into a number of reduced alcohol products that might be less capable of forming covalent adducts with protei...