Review: Peptide, Peptidomimetic and Small-molecule Drug Discovery Targeting HIV-1 Host-cell Attachment and Entry through gp120, gp41, CCR5 and CXCR4

• Published in: Chemical biology & drug design Vol. 67; no. 1; pp. 13 - 26
• Main Authors: Kazmierski, Wieslaw M, Kenakin, Terry P, Gudmundsson, Kristjan S
• Format: Journal Article
• Language: English
• Published: 01.01.2006
• Subjects: Human immunodeficiency virus 1

This review highlights selected examples of peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 to advance novel anti-HIV pharmaceuticals that inhibit initial stages of the viral cycle; namely, attachment and entry. Some of these approaches have culminated in the development of...