DNA-Dependent Conformational Changes in the Ku Heterodimer super([dagger])

Ionizing radiation induces DNA double-strand breaks which are repaired by the nonhomologous end joining (NHEJ) pathway. NHEJ is initiated upon Ku binding to the DNA ends and facilitating an interaction with the DNA- dependent protein kinase catalytic subunit (DNA-PKcs). This heterotrimeric DNA-PK co...

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Bibliographic Details
Published inBiochemistry (Easton) Vol. 47; no. 15; pp. 4359 - 4368
Main Authors Turchi, John J, Lehman, Jason A, Hoelz, Derek J
Format Journal Article
LanguageEnglish
Published 01.01.2008
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