Reviews and feature article: T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4 T cells

• Published in: Journal of allergy and clinical immunology Vol. 123; no. 4; pp. 813 - 823.e3
• Main Authors: Kaminuma, Osamu, Kitamura, Fujiko, Miyatake, Shoichiro, Yamaoka, Kazuko, Miyoshi, Hiroyuki, Inokuma, Shigeko, Tatsumi, Hideki, Nemoto, Soichi, Kitamura, Noriko, Mori, Akio, Hiroi, Takachika
• Format: Journal Article
• Language: English
• Published: 01.04.2009

Background Regardless of TH1/TH2 theory, CD4+ T cells of patients with allergic asthma, a typical TH2 disease, and those of healthy subjects expressed equivalent levels of IFN- gamma , even though TH2 cytokines were significantly upregulated in asthmatic patients. Objective The mechanisms underlying...