Experimental Parathyroid Hormone Gene Therapy Using OeC31 Integrase

• Published in: Endocrine journal Vol. 55; no. 6; pp. 1033 - 1041
• Main Authors: Lee, Sihoon, Hong, Soon Won, Choi, Han Seok, Lee, Lee Young, Nam, Chunja, Rhee, Yumie, Chung, Ung-Il, Lim, Sung-Kil
• Format: Journal Article
• Language: English
• Published: 01.01.2008

OeC31 integrase can integrate targeted plasmid DNA into preferred locations in mammalian genomes, resulting in robust, long-term expression of the integrated transgene. This system represents an effective tool that opens up promising possibilities for gene therapy. The classical treatment for hypopa...