Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a classA beta -lactamase

• Published in: The FEBS journal Vol. 275; no. 20; pp. 5150 - 5160
• Main Authors: Ruth, Nadia, Quinting, Birgit, Mainil, Jacques, Hallet, Bernard, Frere, Jean-Marie, Huygen, Kris, Galleni, Moreno
• Format: Journal Article
• Language: English
• Published: 01.10.2008
• Subjects: Human immunodeficiency virus

Insertion of heterologous peptide sequences into a protein carrier may impose structural constraints that could help the peptide to adopt a proper fold. This concept could be the starting point for the development of a new generation of safe subunit vaccines based on the expression of poorly immunog...