The propagation of hamster-adapted scrapie PrPSc can be enhanced by reduced pyridine nucleotide invitro

• Published in: The FEBS journal Vol. 276; no. 6; pp. 1536 - 1545
• Main Authors: Shi, Song, Dong, Chen-Fang, Tian, Chan, Zhou, Rui-Min, Xu, Kun, Zhang, Bao-Yun, Gao, Chen, Han, Jun, Dong, Xiao-Ping
• Format: Journal Article
• Language: English
• Published: 01.03.2009

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are fatal neurodegenerative disorders caused by an infectious agent termed a prion, which can convert normal cellular prion protein (PrPC) into a pathologically misfolded isoform (PrPSc). Taking advantage of protein misfolding cycl...