Notes & Tips: Ionic liquids promote amyloid formation from alpha -synuclein

The slow process required for alpha -synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha -synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils ca...

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Published inAnalytical biochemistry Vol. 386; no. 2; pp. 293 - 295
Main Authors Hwang, Heejin, Choi, Hyunghun, Kim, Hyun-kyung, Jo, Do Hyun, Kim, T Doohun
Format Journal Article
LanguageEnglish
Published 01.03.2009
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Summary:The slow process required for alpha -synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha -synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha -synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha -synuclein.
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ISSN:0003-2697
DOI:10.1016/j.ab.2008.12.019