Fibrillar amyloid-b burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 16; pp. 6820 - 6825
• Main Authors: Reiman, Eric M, Chen, Kewei, Liu, Xiaofen, Bandy, Daniel, Yu, Meixiang, Lee, Wendy, Ayutyanont, Napatkamon, Keppler, Jennifer, Reeder, Stephanie A, Langbaum, Jessica BS, Alexander, Gene E, Klunk, William E, Mathis, Chester A, Price, Julie C, Aizenstein, Howard J, DeKosky, Steven T, Caselli, Richard J
• Format: Journal Article
• Language: English
• Published: 21.04.2009

Fibrillar amyloid-beta (Ab) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used Pittsburgh Compound B (PiB) PET to characterize the relationship between fibrillar Ab burden and this predisp...