Vitamin D and colon cancer: Gene regulation and interplay with Wnt signalling and SNAIL1

• Published in: Anticancer research Vol. 28; no. 3A; p. 1621
• Main Authors: Munoz, A, Ordonez-Moran, P, Larriba, MJ, Pendas-Franco, N, Aguilera, O, Gonzalez-Sancho, J M
• Format: Journal Article
• Language: English
• Published: 01.06.2008

Previously we demonstrated that 1,25(OH) sub(2)D sub(3) induces Ecadherin and promotes differentiation of human colon cancer cells. In addition, 1,25(OH) sub(2)D sub(3) antagonizes the Wnt/ beta e-catenin signalling, which is aberrantly activated in most human colon cancers, a) by increasing the amo...