Displacement of alpha -Actinin from the NMDA Receptor NR1 C0 Domain By Ca super(2+)/Calmodulin Promotes CaMKII Binding

• Published in: Biochemistry (Easton) Vol. 46; no. 29; pp. 8485 - 8497
• Main Authors: Merrill, MA, Malik, Z, Akyol, Z, Bartos, JA, Leonard, A S, Hudmon, A, Shea, MA, Hell, J W
• Format: Journal Article
• Language: English
• Published: 24.07.2007

Ca super(2+) influx through the N-methyl-D-aspartate (NMDA)-type glutamate receptor triggers activation and postsynaptic accumulation of Ca super(2+)/calmodulin-dependent kinase II (CaMKII). CaMKII, calmodulin, and alpha -actinin directly bind to the short membrane proximal C0 domain of the C-termin...