Naphthyl piperazines with dual activity as 5-HT sub(1D) antagonists and 5- HT reuptake inhibitors

SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 17; no. 12; pp. 3344 - 3348
Main Authors Bueno, Ana B, Gilmore, Jeremy, Boot, John, Broadmore, Richard, Cooper, Jane, Findlay, Jeremy, Hayhurst, Lorna, Marcos, Alicia, Montero, Carlos, Mitchell, Stephen, Timms, Graham, Tomlinson, Rosemarie, Wallace, Louise, Walton, Leslie
Format Journal Article
LanguageEnglish
Published 01.06.2007
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ISSN0960-894X
1464-3405
DOI10.1016/j.bmcl.2007.03.101

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Summary:SAR around a known molecule with dual 5-HT sub(1D) antagonist and 5- HT sub(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT sub(1B), alpha sub(1), and D sub(2)).
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.03.101