Recent advances in selective alpha sub(1)-adrenoreceptor antagonists as antihypertensive agents

• Published in: Bioorganic & medicinal chemistry Vol. 16; no. 9; pp. 4759 - 4800
• Main Authors: Jain, Kishor S, Bariwal, Jitender B, Kathiravan, Muthu K, Phoujdar, Manisha S, Sahne, Rajkumari S, Chauhan, Bishram S, Shah, Anamik K, Yadav, Mange Ram
• Format: Journal Article
• Language: English
• Published: 01.05.2008
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2008.02.091

Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients. Selective alpha sub(1)- adrenoreceptor antagonists though have many advantages and uses in the management of arterial hypertension, their lack of specificity at the level of alpha sub(1)-adr subtypes leads to multiple side effects. Existence of multiple alpha sub(1)-adr subtypes holds great promise for the discovery and development of more specific and selective drug molecules, targeting only one alpha sub(1)-adr subtype at a time and thus relative freedom from side effects. Herein, the research done on the discovery and evaluation of a variety of chemically diverse structures as selective antagonists of alpha sub(1)-adr and alpha sub(1)-adr subtypes in recent years has been reviewed.