Protein tyrosine kinase p56 super(l) super(c) super(k)-deficiency confers hypersusceptibility to rho -fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells

• Published in: Biochemical and biophysical research communications Vol. 377; no. 1; pp. 280 - 285
• Main Authors: Park, H S, Jun, D Y, Han, C R, Kim, Y H
• Format: Journal Article
• Language: English
• Published: 05.12.2008

Phenylalanine analog, rho -fluorophenylalanine (pFPhe)-mediated cytotoxicity and several apoptotic events including mitochondrial cytochrome c release, activation of caspase-9, -3, and -8, Bid cleavage, degradation of PARP and PLC gamma -1, and DNA fragmentation were more significant in p56 super(l)...