Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Mueller glia cells

• Published in: Human molecular genetics Vol. 15; no. 18; pp. 2659 - 2672
• Main Authors: van Rossum, Agnes GSH, Aartsen, Wendy M, Meuleman, Jan, Klooster, Jan, Malysheva, Anna, Versteeg, Inge, Arsanto, Jean-Pierre, Le Bivic, Andre, Wijnholds, Jan
• Format: Journal Article
• Language: English
• Published: 01.09.2006

Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal diseases including Leber's congenital amaurosis (LCA) and retinitis pigmentosa type 12. The CRB1 transmembrane protein localizes at a subapical region (SAR) above intercellular adherens junctions between photoreceptor and Muell...