Novel ligands for the human histamine H sub(1) receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes

• Published in: Bioorganic & medicinal chemistry Vol. 14; no. 19; pp. 6640 - 6658
• Main Authors: Ghoneim, Ola M, Legere, Jacqueline A, Golbraikh, Alexander, Tropsha, Alexander, Booth, Raymond G
• Format: Journal Article
• Language: English
• Published: 01.10.2006

This paper reports the synthesis of a novel series of (+/-)-2-dimethylamino- 5- and 6-phenyl-1,2,3,4-tetrahydronaphthalene derivatives (5- and 6-APTs), and, corresponding affinity, functional activity, and, molecular modeling studies with regard to drug design targeting the human histamine H sub(1)...