Peroxisome Proliferator Activator Receptor- gamma Ligands, 15-Deoxy-[Delta] super(12,14)-Prostaglandin J sub(2) and Ciglitazone, Reduce Systemic Inflammation in Polymicrobial Sepsis by Modulation of Signal Transduction Pathways

• Published in: The Journal of immunology (1950) Vol. 171; no. 12; pp. 6827 - 6837
• Main Authors: Zingarelli, B, Sheehan, M, Hake, P W, O'Connor, M, Denenberg, A, Cook, JA
• Format: Journal Article
• Language: English
• Published: 01.01.2003
• Subjects: ciglitazone; polymicrobial sepsis; PPAR^g ligands

Peroxisome proliferator activator receptor- gamma (PPAR gamma ) is a nuclear receptor that controls the expression of several genes involved in metabolic homeostasis. We investigated the role of PPAR gamma during the inflammatory response in sepsis by the use of the PPAR gamma ligands, 15-deoxy- [De...