The oncogenic RAS2 super(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS

• Published in: The EMBO journal Vol. 22; no. 13; pp. 3337 - 3345
• Main Authors: Hlavata, L, Aguilaniu, H, Pichova, A, Nystroem, T
• Format: Journal Article
• Language: English
• Published: 01.07.2003

The RAS2 super(val19) allele, which renders the cAMP-PKA pathway constitutively active and decreases the replicative life-span of yeast cells, is demonstrated to increase production of reactive oxygen species (ROS) and to elevate oxidative protein damage. Mito chondrial respiration in the mutant is...