Isolation, Structure, and Activity of GID, a Novel [alpha]4/7-Conotoxin with an Extended N-terminal Sequence

• Published in: The Journal of biological chemistry Vol. 278; no. 5; pp. 3137 - 3144
• Main Authors: Nicke, A, Loughnan, M L, Millard, EL, Alewood, P F, Adams, D J, Daly, N L, Craik, D J, Lewis, R J
• Format: Journal Article
• Language: English
• Published: 31.01.2003
• Subjects: alpha -conotoxin; alpha -conotoxin GID; Conus geographus; Marine

Using assay-directed fractionation of Conus geographus crude venom, we isolated [alpha]-conotoxin GID, which acts selectively at neuronal nicotinic acetylcholine receptors (nAChRs). Unlike other neuronally selective [alpha]-conotoxins, [alpha]-GID has a four amino acid N-terminal tail, [gamma]-carbo...