(C sub(6)F sub(5)) sub(3)B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with alpha -Aryl alpha -Diazoesters
The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with alpha -aryl alpha -diazoacetates with commer...
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Published in | Angewandte Chemie Vol. 128; no. 47; pp. 15027 - 15031 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
01.11.2016
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Subjects | |
Online Access | Get full text |
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Summary: | The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with alpha -aryl alpha -diazoacetates with commercially available (C sub(6)F sub(5)) sub(3)B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.Original Abstract: Herausforderung gemeistert: Kommerziell erhaeltliches (C sub(6)F sub(5)) sub(3)B als Katalysator ermoglicht die chemo- und ortho-selektive Substitution von Phenolen mit [alpha]-Aryl-[alpha]-diazoacetaten. Die Reaktion laeuft unter milden Bedingungen mit hoher Effizienz ab, zeichnet sich durch eine grose Substratbreite aus und kann leicht skaliert werden. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.201608937 |