[beta] sub(2) Adrenergic Receptor Activation. MODULATION OF THE PROLINE KINK IN TRANSMEMBRANE 6 BY A ROTAMER TOGGLE SWITCH

• Published in: The Journal of biological chemistry Vol. 277; no. 43; pp. 40989 - 40996
• Main Authors: Shi, L, Liapakis, G, Xu, R, Guarnieri, F, Ballesteros, JA, Javitch, JA
• Format: Journal Article
• Language: English
• Published: 25.10.2002

In many rhodopsin-like G-protein-coupled receptors, agonist binding to a cluster of aromatic residues in TM6 may promote receptor activation by altering the configuration of the TM6 Pro-kink and by the subsequent movement of the cytoplasmic end of TM6 away from TM3. We hypothesized that the highly c...