p16 super(INK4a) Lesions Are Common, Early Abnormalities that Undergo Clonal Expansion in Barrett's Metaplastic Epithelium

• Published in: Cancer research (Chicago, Ill.) Vol. 61; no. 22; pp. 8284 - 8289
• Main Authors: Wong, D J, Paulson, T G, Prevo, L J, Galipeau, P C, Longton, G, Blount, P L, Reid, B J
• Format: Journal Article
• Language: English
• Published: 15.11.2001

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma, a cancer of which the incidence has been increasing at an alarming rate in Western countries. p16 super(INK4a) lesions occur frequently in esophageal adenocarcinomas but their role in neoplastic progression is no...