PIP sub( 2) in pancreatic beta -cells regulates voltage-gated calcium channels by a voltage-independent pathway

• Published in: American Journal of Physiology: Cell Physiology Vol. 311; no. 4; p. C630
• Main Authors: de la Cruz, Lizbeth, Puente, Erika I, Reyes-Vaca, Arturo, Arenas, Isabel, Garduno, Julieta, Bravo-Martinez, Jorge, Garcia, David E
• Format: Journal Article
• Language: English
• Published: 01.10.2016

Phosphatidylinositol-4,5-bisphosphate (PIP sub( 2)) is a membrane phosphoinositide that regulates the activity of many ion channels. Influx of calcium primarily through voltage-gated calcium (Ca sub( V)) channels promotes insulin secretion in pancreatic beta -cells. However, whether Ca sub( V) chann...