Abstract 3172: Comprehensive analysis of intrahepatic cholangiocarcinoma based on viral infections and mutational status in the IDH12 and KRAS genes

Background: Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with poor prognosis and limited therapeutic options. Recently comprehensive genetic profiles have elucidated novel fusion genes and somatic mutations. Although somatic mutations in the isocitrate dehydrogenase (IDH) and KRAS...

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Published inCancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 3172
Main Authors Yasui, Kazuya, Nagasaka, Takeshi, Umeda, Yuzo, Fuji, Tomokazu, Taniguchi, Fumitaka, Toshima, Toshiaki, Kimura, Keisuke, Kawai, Takashi, Mori, Yoshiko, Tazawa, Hiroshi, Yagi, Takahito, Goel, Ajay, Fujiwara, Toshiyoshi
Format Journal Article
LanguageEnglish
Published 15.07.2016
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Summary:Background: Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with poor prognosis and limited therapeutic options. Recently comprehensive genetic profiles have elucidated novel fusion genes and somatic mutations. Although somatic mutations in the isocitrate dehydrogenase (IDH) and KRAS gene were frequently found in ICC, the clinical features of this malignancy with mutations in these genes remain unclear.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2016-3172