Strain-promoted sydnone bicyclo-6.1.0-nonyne cycloaddition†Electronic supplementary information (ESI) available: Full experimental details, 1H/13C NMR spectral data, protein synthesis and purification. See DOI: 10.1039/c3sc53332h

• Published in: Chemical science (Cambridge) Vol. 5; no. 5; p. 1742
• Main Authors: Wallace, Stephen, Chin, Jason W
• Format: Journal Article
• Language: English
• Published: 01.04.2014

The discovery and exploration of bioorthogonal chemical reactions and the biosynthetic incorporation of their components into biomolecules for specific labelling is an important challenge. Here we describe the reaction of a phenyl sydnone 1,3-dipole with a bicyclononyne dipolarophile. This strain-pr...