Phosphorylation and Cell Cycle-dependent Regulation of Na super(+)/H super(+) Exchanger Regulatory Factor-1 by Cdc2 Kinase

• Published in: The Journal of biological chemistry Vol. 276; no. 45; pp. 41559 - 41565
• Main Authors: He, J, Lau, A G, Yaffe, M B, Hall, R A
• Format: Journal Article
• Language: English
• Published: 09.11.2001
• Subjects: Cdc2 protein; Na+/H+ exchanger regulatory factor 1; NHERF-1 protein; Pin1 protein

Na super(+)/H super(+) exchanger regulatory factor (NHERF)-1 is a PDZ domain-containing adaptor protein known to bind to various receptors, channels, cytoskeletal elements, and cytoplasmic signaling proteins. We report here that the phosphorylation state of NHERF-1 is profoundly regulated by the cel...