Enhancement of Mast Cell Survival: A Novel Function of Some Secretory Phospholipase A sub(2) Isotypes

• Published in: The Journal of immunology (1950) Vol. 167; no. 8; pp. 4161 - 4171
• Main Authors: Fonteh, AN, Marion, C R, Barham, B J, Edens, M B, Atsumi, G, Samet, J M, High, K P, Chilton, F H
• Format: Journal Article
• Language: English
• Published: 15.10.2001
• Subjects: I^KB^a protein

This study tested the hypothesis that certain secretory phospholipase A sub(2) (sPLA sub(2)) isotypes act in a cytokine-like fashion through cell surface receptors to influence mast cell survival. Initial experiments revealed that sPLA sub(2) activity and sPLA sub(2) receptor expression are increase...