Antibodies against alpha-fodrin in Sjoegren's syndrome

Alpha-fodrin is a part of the membrane skeleton and expressed in the majority of mammalian cells. It is cleaved in apoptosis by caspase 3. One of the cleavage products, a 120-kDa protein, represents a neoantigen. Antibodies against that cleavage product of alpha-fodrin have originally been described...

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Published inAutoimmunity reviews Vol. 2; no. 2; pp. 109 - 113
Main Authors Ulbricht, K U, Schmidt, R E, Witte, T
Format Journal Article
LanguageEnglish
Published 01.03.2003
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Abstract Alpha-fodrin is a part of the membrane skeleton and expressed in the majority of mammalian cells. It is cleaved in apoptosis by caspase 3. One of the cleavage products, a 120-kDa protein, represents a neoantigen. Antibodies against that cleavage product of alpha-fodrin have originally been described in a murine model of Sjoegren's syndrome. In addition, they are also present in up to 93% of patients with Sjoegren's syndrome, depending on the stringency of the classification used. Although antibodies against alpha-fodrin are observed in other diseases characterized by chronic apoptosis, they are a valuable laboratory marker in the evaluation of Sjoegren's syndrome.
AbstractList Alpha-fodrin is a part of the membrane skeleton and expressed in the majority of mammalian cells. It is cleaved in apoptosis by caspase 3. One of the cleavage products, a 120-kDa protein, represents a neoantigen. Antibodies against that cleavage product of alpha-fodrin have originally been described in a murine model of Sjoegren's syndrome. In addition, they are also present in up to 93% of patients with Sjoegren's syndrome, depending on the stringency of the classification used. Although antibodies against alpha-fodrin are observed in other diseases characterized by chronic apoptosis, they are a valuable laboratory marker in the evaluation of Sjoegren's syndrome.
Author Ulbricht, K U
Schmidt, R E
Witte, T
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