Monomeric IgE Stimulates NFAT Translocation Into the Nucleus, a Rise in Cytosol Ca super(2+), Degranulation, and Membrane Ruffling in the Cultured Rat Basophilic Leukemia-2H3 Mast Cell Line

• Published in: The Journal of immunology (1950) Vol. 172; no. 7; pp. 4048 - 4058
• Main Authors: Pandey, V, Mihara, S, Fensome-Green, A, Bolsover, S, Cockcroft, S
• Format: Journal Article
• Language: English
• Published: 01.04.2004

Mast cells are key regulators in allergy and inflammation, and release histamine, cytokines, and other proinflammatory mediators. In the classical view, IgE acts merely to prime mast cells, attaching to Fc epsilon Rs but not evoking any cell signaling response until cross-linked by the presence of a...