Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA super(UUA) Molecule

• Published in: Chembiochem : a European journal of chemical biology Vol. 16; no. 17; pp. 2498 - 2506
• Main Authors: Zhu, Xi Ming, Hackl, Stefanie, Thaker, Maulik N, Kalan, Lindsay, Weber, Claudia, Urgast, Dagmar S, Krupp, Eva M, Brewer, Alyssa, Vanner, Stephanie, Szawiola, Anjuli, Yim, Grace, Feldmann, Jorg, Bechthold, Andreas, Wright, Gerard D, Zechel, David L
• Format: Journal Article
• Language: English
• Published: 01.11.2015
• Subjects: Streptomyces

Nucleocidin is one of the very few natural products known to contain fluorine. Mysteriously, the nucleocidin producer Streptomyces calvus ATCC13382 has not been observed to synthesize the compound since its discovery in 1956. Here, we report that complementation of S. calvus ATCC13382 with a functio...