Clonal anergy induced in a CD8 super(+) hapten-specific cytotoxic T-cell clone by an altered hapten-peptide ligand

• Published in: Immunology Vol. 102; no. 1; pp. 8 - 14
• Main Authors: Preckel, T, Hellwig, S, Pflugfelder, U, Lappin, M B, Weltzien, HU
• Format: Journal Article
• Language: English
• Published: 01.01.2001
• Subjects: CD8 antigen

Clonal T-cell anergy has been proposed as a mechanism to ensure peripheral tolerance in vivo. Anergy has been reported to result from T cell activation with inappropriate antigen-presenting cells (APC) or, in the case of CD4 super(+) T cells, also by altered peptide ligands. This study reveals that...