Adenovirus-mediated gene transfer of Lp-PLA sub(2) reduces LDL degradation and foam cell formation in vitro

• Published in: Journal of lipid research Vol. 45; no. 9; pp. 1633 - 1639
• Main Authors: Turunen, Paeivi, Jalkanen, Johanna, Heikura, Tommi, Puhakka, Hanna, Karppi, Jouni, Nyyssoenen, Kristiina, Ylae-Herttuala, Seppo
• Format: Journal Article
• Language: English
• Published: 01.09.2004
• Subjects: Adenovirus

Oxidation of LDL generates biologically active platelet-activating factor (PAF)-like phospholipid derivatives, which have potent proinflammatory activity. These products are inactivated by lipoprotein-associated phospholipase A sub(2) (Lp-PLA sub(2)), an enzyme capable of hydrolyzing PAF-like phosph...