Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors: e0149845

• Published in: PloS one Vol. 11; no. 2
• Main Authors: Rietz, Anne, Petrov, Dino P, Bartolowits, Matthew, DeSmet, Marsha, Davisson, V Jo, Androphy, Elliot J
• Format: Journal Article
• Language: English
• Published: 01.02.2016
• Subjects: Human papillomavirus

The human papillomavirus (HPV) HPV E6 protein has emerged as a central oncoprotein in HPV-associated cancers in which sustained expression is required for tumor progression. A majority of the E6 protein interactions within the human proteome use an alpha-helix groove interface for binding. The UBE3A...