Desensitization of IP sub(3)-induced Ca super(2+) release by overexpression of a constitutively active Gq alpha protein converts ventral to dorsal fate in Xenopus early embryos

• Published in: Development, growth & differentiation Vol. 42; no. 4; pp. 327 - 335
• Main Authors: Kume, Shoen, Saneyoshi, Takeo, Mikoshiba, Katsuhiko
• Format: Journal Article
• Language: English
• Published: 01.08.2000
• Subjects: Xenopus

The constitutively active Gq alpha mutant construct (Gq alpha Q-L) in Xenopus early embryos was overexpressed and the effects on dorsoventral patterning examined. It was found that prolonged stimulation of inositol 1,4,5-trisphosphate (IP sub(3))-Ca super(2+) signaling by overexpression of Gq alpha...