A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages: e0146856

• Published in: PloS one Vol. 11; no. 1
• Main Authors: Wang, Maorong, Zheng, Wenkai, Zhu, Xuhui, Xu, Jing, Cai, Binggang, Zhang, Yiqing, Zheng, Feng, Zhou, Linfu, Yang, Zhiguo, Zhang, Xin
• Format: Journal Article
• Language: English
• Published: 01.01.2016
• Subjects: Escherichia coli

The results of clinical and experimental studies suggest that endotoxin/toll-like receptor 4 (TLR4)-mediated proinflammatory and profibrotic signaling activation is critical in the development of hepatic fibrosis. However, studies examining the role of specific TLR4 inhibitor are still lacking. The...