A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization: e0132333

• Published in: PloS one Vol. 10; no. 7
• Main Authors: Parrish, Heather L, Glassman, Caleb R, Keenen, Madeline M, Deshpande, Neha R, Bronnimann, Matthew P, Kuhns, Michael S
• Format: Journal Article
• Language: English
• Published: 01.07.2015

CD4 interactions with class II major histocompatibility complex (MHC) molecules are essential for CD4+ T cell development, activation, and effector functions. While its association with p56lck (Lck), a Src kinase, is important for these functions CD4 also has an Lck-independent role in TCR signaling...