Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitroand zebrafish in vivo

• Published in: Organic & biomolecular chemistry Vol. 11; no. 39; pp. 6680 - 6685
• Main Authors: Babu, PVijaya, Mukherjee, Soumita, Deora, Girdhar Singh, Chennubhotla, Keerthana Sarma, Medisetti, Raghavender, Yellanki, Swapna, Kulkarni, Pushkar, Sripelly, Shivashankar, Parsa, Kishore VL, Chatti, Kiranam, Mukkanti, K, Pal, Manojit
• Format: Journal Article
• Language: English
• Published: 01.09.2013
• Subjects: Danio rerio; Freshwater

A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines has been designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramolecular Heck cyclization strategy was used to prepare these compounds, some of which showed significant in...