Selective down-regulation of [ super(125)I]Y sub(0)- alpha -conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine

• Published in: Neuroscience Vol. 137; no. 2; pp. 565 - 572
• Main Authors: Mugnaini, M, Garzotti, M, Sartori, I, Pilla, M, Repeto, P, Heidbreder, CA, Tessari, M
• Format: Journal Article
• Language: English
• Published: 01.01.2006

Prolonged exposure to nicotine, as occurs in smokers, results in up-regulation of all the neuronal nicotinic acetylcholine receptor subtypes studied so far, the only differences residing in the extent and time course of the up-regulation. alpha 6 beta 2*-Nicotinic acetylcholine receptors are selecti...