INCREASED VASCULAR SELECTIVITY AND PROLONGED PHARMACOLOGICAL EFFICACY OF THE L-TYPE Ca super(2+) CHANNEL ANTAGONIST LERCANIDIPINE IN HUMAN CARDIOVASCULAR TISSUE

• Published in: Clinical and experimental pharmacology & physiology Vol. 32; no. 9; pp. 708 - 713
• Main Authors: Brixius, Klara, Gross, Thomas, Tossios, Paschalios, Geissler, Hans-Joachim, Mehlhorn, Uwe, Schwinger, Robert Hg, Hekmat, Khosro
• Format: Journal Article
• Language: English
• Published: 01.09.2005

1. The present study investigates the vasoselectivity of lercanidipine (LER), a 1,4-dihydropyridine calcium channel blocker, compared with amlodipine (AML) and nifedipine (NIF) in human cardiovascular tissue. Experiments were performed either in human left ventricular failing myocardium (orthotopic...