Sequence Selective Cleavage of a DNA Octanucleotide by Chlorinated Bithiazoles and Bleomycins

• Published in: Journal of the American Chemical Society Vol. 120; no. 36; pp. 9368 - 9369
• Main Authors: Zuber, G, Quada, JC Jr, Hecht, S M
• Format: Journal Article
• Language: English
• Published: 01.09.1998
• Subjects: bleomycin

The bleomycins (BLM) are a family of clinically used antitumor antibiotics. Their mechanism of action is believed to involve the degradation of DNA and possibly of RNA. BLM-mediated degradation requires a redox-active metal ion as well as oxygen and involves the intermediacy of a metal-bound oxo or...