p75 super(NTR) independent oligodendrocyte death in cuprizone-induced demyelination in C57BL-6 mice
Feeding C57Bl-6 J mice the copper chelator cuprizone leads to selective apoptosis of mature oligodendrocytes and concomitant demyelination predominantly in the corpus callosum. The process of oligodendrocyte apoptosis in this animal model for multiple sclerosis (MS) involves early microglial activat...
Saved in:
Published in | Neuropathology and applied neurobiology Vol. 31; no. 6; pp. 600 - 609 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
01.12.2005
|
Online Access | Get full text |
Cover
Loading…
Abstract | Feeding C57Bl-6 J mice the copper chelator cuprizone leads to selective apoptosis of mature oligodendrocytes and concomitant demyelination predominantly in the corpus callosum. The process of oligodendrocyte apoptosis in this animal model for multiple sclerosis (MS) involves early microglial activation, but no infiltration of T-lymphocytes. Therefore, this model could mimic early stages of oligodendrocyte degeneration Affected oligodendrocytes express the common neurotrophin receptor, p75 super(NTR), a 'stress-receptor' which under certain circumstances can induce apoptosis. Only affected oligodendrocytes in MS lesions and MS animal models express this receptor. In order to study the significance of p75 super(NTR) in the fate of oligodendrocytes, we have exposed wild-type as well as p75 super(NTR)-knockout mice to a 0.2% (w-w) cuprizone diet and performed a comparative immunohistochemical analysis of the corpus callosum at various time points. Surprisingly, our results show that the absence of p75 super(NTR) did not alter cuprizone-induced oligodendrocyte death (and subsequent de- or remyelination). Apparently, intracellular apoptosis pathways in adult oligodendrocytes do not require p75 super(NTR) activated signal transduction in the absence of T-lymphocytes and T-lymphocyte derived cytokines. |
---|---|
AbstractList | Feeding C57Bl-6 J mice the copper chelator cuprizone leads to selective apoptosis of mature oligodendrocytes and concomitant demyelination predominantly in the corpus callosum. The process of oligodendrocyte apoptosis in this animal model for multiple sclerosis (MS) involves early microglial activation, but no infiltration of T-lymphocytes. Therefore, this model could mimic early stages of oligodendrocyte degeneration Affected oligodendrocytes express the common neurotrophin receptor, p75 super(NTR), a 'stress-receptor' which under certain circumstances can induce apoptosis. Only affected oligodendrocytes in MS lesions and MS animal models express this receptor. In order to study the significance of p75 super(NTR) in the fate of oligodendrocytes, we have exposed wild-type as well as p75 super(NTR)-knockout mice to a 0.2% (w-w) cuprizone diet and performed a comparative immunohistochemical analysis of the corpus callosum at various time points. Surprisingly, our results show that the absence of p75 super(NTR) did not alter cuprizone-induced oligodendrocyte death (and subsequent de- or remyelination). Apparently, intracellular apoptosis pathways in adult oligodendrocytes do not require p75 super(NTR) activated signal transduction in the absence of T-lymphocytes and T-lymphocyte derived cytokines. |
Author | Kuest, B M Boddeke, HWGM Copray, JCVM Mantingh-Otter, I |
Author_xml | – sequence: 1 givenname: JCVM surname: Copray fullname: Copray, JCVM – sequence: 2 givenname: B surname: Kuest middlename: M fullname: Kuest, B M – sequence: 3 givenname: I surname: Mantingh-Otter fullname: Mantingh-Otter, I – sequence: 4 givenname: HWGM surname: Boddeke fullname: Boddeke, HWGM |
BookMark | eNqNzsFKAzEQBuAgFdy2vkNOoofEyW6TuFeL0oN4kN7Lkh01JZvETQLWpzeCeHYOMz_832GWZOGDR0KoAC7q3B656JRkbd8DbwEkB1BS8c8z0vwVC9JAB5KJu426IMuUjlClVn1DTNSSphJxvn7ev9xQ60eMWJfPNDj7Fmoa52BOGemIQ36vgpoSZ_tV_2CVF4NjraYTOuuHbIP_IVup75-YopM1uCbnr4NLePl7V-Tq8WG_3bE4h4-CKR8mmww6N3gMJR2E3nSt0rr7N_wG8zNSFA |
ContentType | Journal Article |
DBID | 7TK |
DOI | 10.1111/j.1365-2990.2005.00656.x |
DatabaseName | Neurosciences Abstracts |
DatabaseTitle | Neurosciences Abstracts |
DatabaseTitleList | Neurosciences Abstracts |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1365-2990 |
EndPage | 609 |
GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 123 1OB 1OC 29N 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 5HH 5LA 5RE 5VS 66C 702 7PT 7TK 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EAS EBC EBD EBS EBX EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 Q~Q R.K ROL RX1 SUPJJ SV3 TEORI TUS UB1 W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR XG1 YFH ZZTAW ~IA ~WT |
ID | FETCH-proquest_miscellaneous_174326773 |
ISSN | 0305-1846 |
IngestDate | Fri Aug 16 04:42:56 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-proquest_miscellaneous_174326773 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
PQID | 17432677 |
PQPubID | 23462 |
ParticipantIDs | proquest_miscellaneous_17432677 |
PublicationCentury | 2000 |
PublicationDate | 20051201 |
PublicationDateYYYYMMDD | 2005-12-01 |
PublicationDate_xml | – month: 12 year: 2005 text: 20051201 day: 01 |
PublicationDecade | 2000 |
PublicationTitle | Neuropathology and applied neurobiology |
PublicationYear | 2005 |
SSID | ssj0005769 |
Score | 3.5446274 |
Snippet | Feeding C57Bl-6 J mice the copper chelator cuprizone leads to selective apoptosis of mature oligodendrocytes and concomitant demyelination predominantly in the... |
SourceID | proquest |
SourceType | Aggregation Database |
StartPage | 600 |
Title | p75 super(NTR) independent oligodendrocyte death in cuprizone-induced demyelination in C57BL-6 mice |
URI | https://search.proquest.com/docview/17432677 |
Volume | 31 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS8NAEF5qBfFFPPF2H0SUEolpzkdbW4v2gJJq30qSbrGgSWmTB_sH_NvObDZpaovXSwjLsjnmY3Zm9psZQs4NbdD3WFGRFNVTJdV0sc2LJUuuq7iWx8y-xptNNJp6raM-dLVuLveRYS1FoXvtTZfmlfxHqjAGcsUs2T9INl0UBuAe5AtXkDBcfyXjkaEVJtEI_7rZtNvo4Q_TtrZhIXgdgtfJsCSB9x5ighSYexjg8KLReDgNfCbB9AgZAJhVgpnpTsJ9LGtGqS7phTfBjUsMWF7MA9sYz2o3OcKQ5aUxRVGn9GgjGI0d0RT5KQ3yPOJexJE1C8Y2HN6z4kVqhaJXSBrPLQWgHWMSUe35vjEXqNAypA-RoIVjpog4sljfcpKdFXcMTRRy8SYDvKx21WU5s1HrvK7CN3tAsnYSOQPTNeGGZstuN1u9aqde79mVrr1CVhXD0tCLv2vP6pCBU2bFx1HxF8xTwpY-Z2Fv5waLvUk2hKdBb2PYbJEc87fJWkNwKXaIB-ihHD2XgJ0rmkEO_YIcypEDM-gCcugccnCKQA5F5OySi2rFLtek5CV7oFbwrMjxWRBNeuioKrphFPdI3odV9wl1NBeDKZYsO6ZqMWaaKhZPHIDBrfSLOjsgZz8sdvjjjCOyPoPOMcmH44idgNUXuqdcIp-4j1tx |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Wiley-Blackwell |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=p75+super%28NTR%29+independent+oligodendrocyte+death+in+cuprizone-induced+demyelination+in+C57BL-6+mice&rft.jtitle=Neuropathology+and+applied+neurobiology&rft.au=Copray%2C+JCVM&rft.au=Kuest%2C+B+M&rft.au=Mantingh-Otter%2C+I&rft.au=Boddeke%2C+HWGM&rft.date=2005-12-01&rft.issn=0305-1846&rft.eissn=1365-2990&rft.volume=31&rft.issue=6&rft.spage=600&rft.epage=609&rft_id=info:doi/10.1111%2Fj.1365-2990.2005.00656.x&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0305-1846&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0305-1846&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0305-1846&client=summon |