Antiplasmodial Activity of Naphthoquinones Related to Lapachol and [beta]-Lapachone

The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and [beta]-lapachone (2) was tested. ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum, and some derivativ...

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Published inChemistry & biodiversity Vol. 2; no. 2; pp. 264 - 274
Main Authors Perez-Sacau, Elisa, Estevez-Braun, Ana, Ravelo, Angel G, Yapu, David Gutierrez, Turba, Alberto Gimenez
Format Journal Article
LanguageEnglish
Published 01.01.2005
Subjects
Plasmodium falciparum
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Abstract The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and [beta]-lapachone (2) was tested. ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum, and some derivatives displayed attractive in vitro activities (IC sub(50)<10 [mu]M). Based on these results, some structure[bond]activity relationships have been determined.
AbstractList The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and [beta]-lapachone (2) was tested. ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum, and some derivatives displayed attractive in vitro activities (IC sub(50)<10 [mu]M). Based on these results, some structure[bond]activity relationships have been determined.
Author Estevez-Braun, Ana
Turba, Alberto Gimenez
Perez-Sacau, Elisa
Ravelo, Angel G
Yapu, David Gutierrez
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Title Antiplasmodial Activity of Naphthoquinones Related to Lapachol and [beta]-Lapachone
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