EBV super(+) B Lymphoma Cell Lines from Patients with Post-Transplant Lymphoproliferative Disease Are Resistant to TRAIL-Induced Apoptosis

• Published in: American journal of transplantation Vol. 6; no. 5; pp. 976 - 985
• Main Authors: Snow, AL, Vaysberg, M, Krams, S M, Martinez, OM
• Format: Journal Article
• Language: English
• Published: 01.05.2006
• Subjects: Epstein-Barr virus

Lymphomas associated with post-transplant lymphoproliferative disease (PTLD) represent a significant complication of immunosuppression in transplant recipients. In immunocompetent individuals, EBV-specific cytotoxic T lymphocytes (CTL) prevent the outgrowth of activated B lymphoblasts through apopto...