Potent effects of low levels of MHC class II-associated invariant chain on CD4 super(+) T cell development

• Published in: Immunity (Cambridge, Mass.) Vol. 3; no. 3; pp. 359 - 372
• Main Authors: Naujokas, M F, Arneson, L S, Fineschi, B, Peterson, ME, Sitterding, S, Hammond, A T, Reilly, C, Lo, D, Miller, J
• Format: Journal Article
• Language: English
• Published: 01.01.1995

Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4 super(+) T cells. Many CD4 super(+) T cells that do mature in Ii-negative mice express...