Histone polyplexes utilize caveolar uptake and traffic through the Golgi and ER during gene transfer

• Published in: Molecular therapy Vol. 20; no. 9; p. 59
• Main Authors: Reilly, Meghan J, Larsen, John D, Sullivan, Millicent O
• Format: Journal Article
• Language: English
• Published: 01.09.2012

Improved control over the subcellular trafficking of polyplexes has been widely identified as a key hurdle towards improving their activity in the in vivo setting, where gene transfer inefficiencies cannot be easily offset by increasing the concentration of the delivered vehicle. It has become incre...