Electrocatalytic Oxidation of Cysteine at a CoSalophen/ n-(butyl) sub(4)SiW sub(12)O sub(40) Carbon Paste Electrode

In the present study, a novel mixture consisting of N,N'-bis(salicylidene)-1,2 -phenylenediamino cobalt (CoSalophen, CoSal) complex and (n-butyl) sub(4)SiW sub(12)O sub(40) (SiW sub(12)), have been used to chemically modify a carbon paste electrode (CPE) for sensitive determination of cysteine...

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Published inElectroanalysis (New York, N.Y.) Vol. 25; no. 9; pp. 2100 - 2108
Main Authors Kakhki, Somayeh, Shams, Esmaeil, Barsan, Madalina M
Format Journal Article
LanguageEnglish
Published 01.09.2013
Subjects
Carbon
Cysteine
Electrodes
Mathematical analysis
Oxidation
Pastes
Sensors
Urine
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Summary:In the present study, a novel mixture consisting of N,N'-bis(salicylidene)-1,2 -phenylenediamino cobalt (CoSalophen, CoSal) complex and (n-butyl) sub(4)SiW sub(12)O sub(40) (SiW sub(12)), have been used to chemically modify a carbon paste electrode (CPE) for sensitive determination of cysteine (CySH). The electrocatalytic effect of the newly developed modified CPE towards oxidation of CySH was evaluated by comparing cyclic and differential pulse voltammograms in the presence of cysteine at bare, CoSal, SiW sub(12) and CoSal/SiW sub(12) modified CPE. The differential pulse voltammetry method was applied as a sensitive method for quantitative detection of CySH trace amounts, the experimental conditions being optimized in order to evaluate the best analytical parameters of the sensor. Reproducibility and stability studies were also performed and the sensor was applied for the determination of CySH in a pharmaceutical sample and in human blood serum and urine samples.
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ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201300235